Ethidium Bromide Induced Histological Changes in Spleen of Albino Mice
نویسندگان
چکیده
Adult Mice (BWt. 30 gms and 40gms) were treated at a 5mg\kgBWt. and 10 mg/kg BWt. of Ethidium Bromide for 10 days in drinking water. Control animals were given equal dose of deionised water. Quantitative and qualitative changes were studied in Spleen. The following features were evaluated: the overall cellularity of the spleen was noticed. The changes were characterised by, injury to spleen tissue; necrotic changes, cirrhosis and fibrosis. Also reduction in visceral epithelial cell number was noticed. The size of the spleen slightly decreased and interstitium shrinked. Also a Slight change in spleen weight was recorded. Body weight of the animal was slightly altered after challenge with Ethidium Bromide.
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